Table 2.

Histologic characteristics of lung adenocarcinomas with ALK rearrangement

CharacteristicsTotal samplesALK rearrangementALK germ-lineP
Signet-ring cells in tumor, n (%)34217 (100)325 (100)<0.0001
    None2953 (18)292 (90)
    ≤10%212 (12)19 (6)
    >10%2612 (71)14 (4)
Dominant histologic pattern, n (%)*32616 (100)310 (100)0.11
    Bronchioloalveolar221 (6)21 (7)
    Acinar1244 (25)120 (39)
    Papillary460 (0)46 (15)
    Solid13411 (69)123 (40)
Solid pattern and >10% signet-ring cells, n (%)*9 (56)9 (3)<0.0001

NOTE: Due to rounding not all percentages total 100.

  • *Tumor architecture was not evaluated in 16 cases where the diagnosis was made only by cytology.