Table 4.

Vorinostat pharmacokinetics

DoseCmax (mmol/L)tmax (h)t1/2 (h)AUCINF (mmol/L*h)CL/F (l/h)CL/F (l/min)
100 mg BID (n = 6)
    Mean0.311.31.30.7660510.1
    SD0.140.40.50.432464.1
200 mg BID (n = 3)
    Mean0.651.32.42.033836.4
    SD0.350.62.30.40821.4
400 mg daily (n = 10)
    Mean1.422.81.65.133135.2
    SD0.321.60.51.22871.4
500 mg daily (n = 3)
    Mean1.333.84.48.102464.1
    SD0.151.93.02.17731.2