Table 3.

Clinical outcomes for rare mutations or rare combinations of mutations

Mutation(s)NResponseTTP, moOS, mo
Suspected sensitizing mutation
    L861Q1SD48.8
    G719A1SD3.95.2
    Exon 19 duplication1PR22.1+22.1+
Suspected resistance mutation
    Exon 20 insertion31 SD, 2 PD1.0 (median)1.5 (median)
Multiple mutations
    Exon 19 del + L861Q + G873E1SD20.534.9+
    L858R + T790M1PD1.917.5
    T790M + KRAS mutation1PD0.80.8
    Exon 19 del + KRAS mutation1SD25.844.7+
    V802I + KRAS mutation1PD0.94.0
    G719A + G779C1PR2.9+2.9+

Abbreviations: SD, stable disease; PR, partial response; PD, progressive disease.