Table 2.

Comparison of continuous infusion and bolus dosing of SS1P

Continuous infusionBolus (30 min) infusion
MTD25 μg/kg/d ×1045 μg/kg QOD ×3
MTD (total dose)250 μg/kg135 μg/kg
Immunogenicity18 (75%) of 2430 (88%) of 34
AUC (median at MTD)1800 μg min/mL590 μg min/mL