Table 2.

Mapatumumab dose levels and DLTs as a function of dose

Dose level (mg/kg)No. of patientsMedian no. of cycles (range)No. of patients with DLT
146 (3-12)0
376 (3-18)0
10126 (1-21)3
20134 (1-48)*2
30135 (1-15)0
  • *One patient is ongoing and received 48 cycles as of January 31, 2009.