Table 1.

Summary of EGFR mutations in pediatric HGGs

WHO gradeAmplification (CISH)vIII deletion (RT-PCR)Extracellular domainKinase domain
All pediatric HGG8/74 (11%)6/35 (17%)0/660/60
Glioblastoma multiformeIV6/43 (14%)1/20 (5%)0/340/30
Brain stem gliomaIV0/30/10/30/2
Anaplastic astrocytomaIII2/11 (18%)2/6 (33%)0/120/12
Anaplastic oligodendrogliomaIII0/42/3 (67%)*0/40/4
Other pediatric HGG0/131/5 (Gliosarcoma)0/130/12
  • Significantly higher than that seen in other tumors (P = 0.036, Fisher's exact test).