Table 4.

TP53 mutations in populations exposed to radon

PopulationExposure (Mean WLM)No. of casesNo. of cases (%) with TP53 mutationsCodon 249 AGG-ATGReference
Uranium miners:
    New Mexico111197 mutations in 5 cases (26%)0Vahakangas et al. (128)
    Colorado1,3825216 (31%)Taylor et al. (125)
    Colorado1,27023NS0McDonald et al. (129)
    Germany1,01150NS0Bartsch et al. (130); Hollstein et al. (131)
    GermanyNK29NS2 (7%)Yang et al. (132)
Environmental exposure:
    England9.217NS0Lo et al. (133)
    Sweden0.2513929 (20.9%)0Yngveson et al. (151)
0.59023 (25.6%)0
2146 (42.9%)0
Missouri, womenNKNonsmokers, 120; Exsmokers 1122 (18%)0Vahakangas et al. (43)
6 (54%)0

Abbreviations: NK, not known; NS, not studied; WLM, working level months (1WLM corresponds to 170 hours in a place where air contains 130,000 MeV of α-radiation in 1 L of air; 1Bq/m3 is equivalent to 0.005 WLM).