Table 1.

Schema for regimens

Dose levelsAC, mg/M2/d (days)Phenylbutyrate, mg/m2/d (days)No. of patientsDays/cycle
A
    A125 (D1-14)400 (D6, D13)335
    A-118.75 (D1-14)400 (D6, D13)3
    A-215 (D1-14)400 (D6, D13)3
    A-310 (D1-14)400 (D6, D13)3
B
    B175 (D1-7)200 (D8-14)3
    B275 (D1-7)400 (D8-14)4*
C
    C110 (D1-21)400 (D6, D13, D20)342
    C212.5 (D1-21)400 (D6, D13, D20)6
  • *One patient did not receive phenylbutyrate.