Table 1.

Median time to oral cancer development (in years) and the OCFS rates at years 5 and 10, along with the 95% CIs for all patients and for each group

VariablenOral cancerMedian (95% CI)OCFS rate at 5 y (95% CI)OCFS rate at 10 y (95% CI)P
All patients1623914.34 (NA)0.8 (0.74-0.87)0.73 (0.66-0.81)
Sex0.80
    Female7718NA0.78 (0.69-0.88)0.73 (0.63-0.85)
    Male852114.34 (NA)0.82 (0.74-0.91)0.73 (0.63-0.85)
Race0.74
    Other173NA0.85 (0.67-1)0.75 (0.54-1)
    White1453614.34 (NA)0.8 (0.73-0.87)0.73 (0.66-0.82)
Histologic status0.05
    Hyperplasia1092214.34 (NA)0.84 (0.78-0.92)0.79 (0.71-0.88)
    Mild dysplasia4011NA0.75 (0.63-0.91)0.67 (0.53-0.86)
    Moderate/severe dysplasia1366.67 (1.85-NA)0.59 (0.37-0.95)0.47 (0.25-0.9)
Treatment arm0.66
    13cRA8120NA0.78 (0.69-0.88)0.72 (0.62-0.83)
    BC + RP451014.34 (NA)0.84 (0.73-0.96)0.8 (0.69-0.94)
    RP369NA (6.65-NA)0.82 (0.69-0.96)
Smoking history0.26
    Current568NA0.86 (0.77-0.96)0.83 (0.72-0.95)
    Former652114.34 (10.7-NA)0.78 (0.68-0.89)0.67 (0.55-0.81)
    Never4110NA0.77 (0.65-0.91)0.74 (0.61-0.89)
Alcohol history0.74
    Current932114.34 (NA)0.84 (0.76-0.92)0.75 (0.66-0.86)
    Former195NA (6.21-NA)0.78 (0.61-1)0.68 (0.48-0.98)
    Never5013NA0.75 (0.64-0.88)0.72 (0.6-0.87)
Podoplanin expression<0.0001
    0, 1941314.34 (NA)0.93 (0.87-0.99)0.83 (0.74-0.92)
    2, 3, 4562210.7 (6.67-NA)0.63 (0.51-0.77)0.6 (0.47-0.75)
ΔNp63 expression<0.0001
    0-51111714.34 (NA)0.89 (0.83-0.95)0.81 (0.73-0.9)
    6-9411910.7 (3.52-NA)0.61 (0.47-0.78)0.54 (0.4-0.73)
Clusters of EIC0.015
    Absent10818NA0.86 (0.79-0.93)0.79 (0.71-0.89)
    Present371410.7 (6.67-NA)0.72 (0.59-0.89)0.62 (0.47-0.81)
No. positive biomarkers<0.0001
    0, 1, 21402614.34 (NA)0.85 (0.79-0.92)0.78 (0.71-0.87)
    315112.46 (1.62-NA)0.39 (0.2-0.74)0.31 (0.14-0.68)

NOTE: P values from the log-rank test (unicovariate analysis) are also provided.