Table 2.

Lymphocytic reaction score and survival of patients with stage I to IV colorectal cancer

Overall lymphocytic reaction score*Total, n (%)Colorectal cancer–specific survivalOverall survival
Deaths/person-yearsUnivariate HR (95% CI)Stage-matched HR (95% CI)Multivariate HR (95% CI)Deaths/person-yearsUnivariate HR (95% CI)Stage-matched HR (95% CI)Multivariate HR (95% CI)
0-2 (low)549 (65)175/4,3231 (reference)1 (reference)1 (reference)268/4,3231 (reference)1 (reference)1 (reference)
3-6 (middle)230 (27)43/1,9450.55 (0.39-0.76)0.64 (0.45-0.90)0.61 (0.42-0.89)88/1,9450.73 (0.57-0.93)0.80 (0.62-1.02)0.71 (0.54-0.93)
7-12 (high)64 (7.6)7/5420.31 (0.15-0.66)0.60 (0.28-1.30)0.53 (0.23-1.23)17/5420.50 (0.31-0.82)0.74 (0.45-1.23)0.49 (0.28-0.86)
P for trend<0.00010.0080.0080.00040.0500.002

NOTE: The multivariate, stage-matched Cox regression model included age, year of diagnosis, sex, family history of colorectal cancer, tumor location, tumor grade, negative lymph node count, KRAS, BRAF, p53, LINE-1 methylation, MSI, and CIMP.

Abbreviation: 95% CI, 95% confidence interval.

  • ↵*Overall lymphocytic reaction score is the sum of scores for Crohn's-like reaction (0-3), peritumoral reaction (0-3), intratumoral periglandular reaction (0-3), and TIL (0-3).