Table 3.

Lymphocytic reaction component and survival in stage I to IV colorectal cancer

Lymphocytic reactionTotal, nColorectal cancer–specific survivalOverall survival
Deaths/person-yearsStage-matched HR (95% CI)Multivariate HR (95% CI)Deaths/person-yearsStage-matched HR (95% CI)Multivariate HR (95% CI)
Crohn's-like reaction*
    0613188/4,7781 (reference)1 (reference)292/4,7781 (reference)1 (reference)
    1+16829/1,4790.66 (0.42-0.98)0.77 (0.50-1.18)61/1,4790.77 (0.58-1.02)0.80 (0.59-1.09)
    2-3+628/5530.58 (0.28-1.20)0.53 (0.25-1.12)20/5530.76 (0.48-1.21)0.51 (0.31-0.86)
    P for trend0.0200.0520.0590.007
Peritumoral reaction*
    04323/2921 (reference)1 (reference)29/2921 (reference)1 (reference)
    1+707192/5,7490.69 (0.44-1.09)0.72 (0.45-1.15)317/5,7490.78 (0.52-1.16)0.76 (0.50-1.16)
    2-3+9310/7690.40 (0.19-0.87)0.38 (0.17-0.86)27/7690.64 (0.37-1.13)0.48 (0.27-0.87)
    P for trend0.0170.0190.120.014
Intratumoral periglandular reaction*
    03720/2311 (reference)1 (reference)25/2311 (reference)1 (reference)
    1+709194/5,7850.69 (0.43-1.12)0.65 (0.39-1.08)320/5,7850.71 (0.47-1.09)0.67 (0.43-1.04)
    2-3+9711/7940.43 (0.20-0.93)0.37 (0.17-0.84)28/7940.60 (0.34-1.05)0.42 (0.23-0.78)
    P for trend0.0280.0160.0930.005
TIL*
    0624180/5,0541 (reference)1 (reference)290/5,0541 (reference)1 (reference)
    1+12332/9580.87 (0.59-1.27)0.81 (0.53-1.22)51/9580.88 (0.65-1.19)0.77 (0.56-1.07)
    2-3+9613/7980.80 (0.45-1.42)0.72 (0.37-1.40)32/7980.99 (0.68-1.44)0.73 (0.47-1.13)
    P for trend0.320.200.670.066

NOTE: The multivariate, stage-matched Cox regression model included age, year of diagnosis, sex, family history of colorectal cancer, tumor location, tumor grade, negative lymph node count, KRAS, BRAF, p53, LINE-1 methylation, MSI, CIMP, and each of the lymphocytic reaction components listed in the table.

  • *The score represents reaction as follows: 0 (absent); 1+ (mild); 2+ (moderate); 3+ (strong).