Table 1.

Biological functions of nuclear ErbB receptors

Biological FunctionNuclear ErbB Receptor
Cell proliferationErbB-1 (9, 22, 31, 43, 54)
DNA replicationErbB-1 (43)
DNA damage repairErbB-1 (43, 64–66, 71)
TranscriptionErbB-1 (9, 30–32); ErbB-2 (10, 11); ErbB-4 (17, 37, 74)
Cancer progressionErbB-1 (9, 30, 32, 42, 43, 45–47, 51, 63, 66); ErbB-2 (11, 18); ErbB-3 (72); ErbB-4 (75)
DevelopmentErbB-4 (74)