Table 1.

Disease-specific survival analysis of the NKG2D ligands MIC, RAET1E, RAET1G, ULBP1, ULBP2, and ULBP3

VariableMean DSS (mo)Survival range (mo)Log rank PCox regression PHRLower CIUpper CI
MICA expression
    High6862-740.0350.040.760.590.99
    Low5647-65
ULBP1 expression
    High6761-730.0550.0450.810.641.05
    Low5850-66
ULBP2 expression
    High6054-660.4660.391.13
    Low6760-74
ULBP3 expression
    High6658-740.530.4920.91
    Low6357-70
RAET1E expression
    High6558-720.6420.2990.84
    Low6457-71
RAET1G expression
    High7465-830.010.030.740.5511
    Low6256-67
MICA and ULBP1
    Both high6760-730.0180.0060.830.70.97
    Single high6657-74
    Both low5038-62
MICA and RAET1E
    Both high6862-740.020.0140.860.770.97
    Single high6151-72
    Both low4430-59
MICA and RAET1G
    Both high7768-870.0030.0050.840.740.95
    Single high6456-71
    Both low5444-64
ULBP1 and RAET1E
    Both high6859-720.0410.0390.81
    Single high6255-70
    Both low4527-63
ULBP1 and RAET1G
    Both high7363-840.0270.0320.83
    Single high6558-72
    Both low5748-65
RAET1E and RAET1G
    Both high7667-860.0040.0020.840.770.99
    Single low/both low6155-67

NOTE: Data presented for each ligand expression case. Combinations of ligand expression are only presented in cases in which statistical significance was found.

Abbreviations: DSS, disease-specific survival; HR, hazard ratio; CI, confidence interval.