Table 1.

Overview of sample sets used for development of ER, PR, and HER2 readout by immunohistochemistry (local, central, and ASCO/CAP) and TargetPrint microarrays

TotalCohort 1Cohort 2Cohort 3Total
295241100636
ImmunohistochemistryTissueTissue microarrayTissue microarrayWhole sections
ERImmunohistochemistryLocal100100
Central28619396575
ASCO/CAP8787
TargetPrint295241100636
Train100100
Validation18619396475
PRImmunohistochemistryLocal100100
Central28619396575
ASCO/CAP8787
TargetPrint295241100636
Train100100
Validation18619396475
HER2Immunohistochemistry/CISHLocal8282
Central27319896567
ASCO/CAP8585
TargetPrint295241100636
Train100100
Validation17319896467

NOTE: “Immunohistochemistry tissue” indicates the type of tissue that was used for immunohistochemical assessment: tissue microarrays or whole sections.