Table 4.

Review of 11 discordant cases with mismatching ER or HER2 microarray and central immunohistochemistry readout by additional microarray readout (review 1), by independent CAP immunohistochemistry/FISH assessment (review 2), and by restaining and/or rescoring of centrally performed immunohistochemistry (review 3)

SampleOriginalReview 1Review 2Review 3
Central immunohistochemistryCentral CISHMicroarrayMicroarrayCAP immunohistochemistryCAP FISHCentral immunohistochemistryCentral CISH
#26 ER60%−0.23−0.2410%10%
#30 ER0%0.620.6090%100%
#57 ER0%0.220.25ND0%
#62 ER100%−0.47−0.4490%100%
#74 ER50%−0.41−0.4190%100%
#92 ER10%−0.20−0.200%5%
#27 HER21+0.460.462+Positive2+Negative
#30 HER200.080.043+Positive2+Borderline
#48 HER22+Positive−0.12−0.193+3+Positive
#62 HER200.530.5700
#94 HER22+Positive−0.07−0.033+2+Positive

NOTE: Assessments resulting in a positive receptor status are shown in bold.