Table 1.

Chemotherapy regimen

RegimenCycle*DrugCycle day
V3DC1, 2, 9, 13Vincristine 2 mg/m2 i.v. push (max, 2 mg)1, 8, 15
Doxorubicin 37.5 mg/m2 i.v. over 15 min1 and 2
Cyclophosphamide 1,200 mg/m2 i.v. over 1 h1 and 2
Dexrazoxane 375 mg/m2 i.v. over 15-30 min before doxorubicin1 and 2
Mesna 360 mg/m2 during cyclophosphamide, immediately after cyclophosphamide, and then every three hours for 3-6 additional doses1 and 2
V1DC5, 11Vincristine 2 mg/m2 i.v. push (max, 2 mg)1
Doxorubicin 37.5 mg/m2 i.v. over 15 min1 and 2
Cyclophosphamide 1,200 mg/m2 i.v. over 1 h1 and 2
Dexrazoxane 375 mg/m2 i.v. over 15-30 min before doxorubicin1 and 2
Mesna 360 mg/m2 during cyclophosphamide, immediately after cyclophosphamide, and then every three hours for 6 additional doses1 and 2
IE3, 4, 6, 7, 8, 10, 12, 14Etoposide 100 mg/m2 i.v. over 60 min1-5
Ifosfamide 1,800 mg/m2 i.v. over 60 min1-5
Mesna 360 mg/m2 during ifosfamide, immediately after ifosfamide, and then every three hours for 6 additional doses1-5

Abbreviations: V3DC, vincristine (three weekly doses), doxorubicin, cyclophosphamide; V1DC, vincristine (single dose), doxorubicin, cyclophosphamide.

  • *Cycle duration was 21 d, but patients must have recovered (see text) from treatment-related toxicity on the prior cycle before starting the subsequent cycle.