Table 2.

Derivation of irRC overall responses

Measurable response	Nonmeasurable response		Overall response
Index and new, measurable lesions (tumor burden),^* %	Non-index lesions	New, nonmeasurable lesions	Using irRC
↓100	Absent	Absent	irCR^†
↓100	Stable	Any	irPR^†
↓100	Unequivocal progression	Any	irPR^†
↓≥50	Absent/Stable	Any	irPR^†
↓≥50	Unequivocal progression	Any	irPR^†
↓<50 to <25↑	Absent/Stable	Any	irSD
↓<50 to <25↑	Unequivocal progression	Any	irSD
≥25?	Any	Any	irPD^†

↵*Decreases assessed relative to baseline, including measurable lesions only (>5 × 5 mm).
↵^†Assuming response (irCR) and progression (irPD) are confirmed by a second, consecutive assessment at least 4 wk apart.