Table 1.

Oncogenic ability of EGFRvIII mutants

MutationGrowth factor independence
EGFRvIIIYes
EGFRvIII + G719SYes
EGFRvIII + L688PNo
EGFRvIII + V851ANo
EGFRvIII + I853TNo
  • NOTE: Ba/F3 cells stably expressing WT or mutant EGFRvIII were analyzed for cytokine-independent growth on IL-3 withdrawal and followed up to 3 wk for survival.