Table 2.

IC50 values of EGFR mutants for the indicated EGFR inhibitors

MutationExonGrowth factor independence of Ba/F3IC50 value (nmol/L)
GefitinibErlotinibAEE788
L858R21Yes1266
Δ747-753insS19Yes755
L688P18No
G719C18No
G719S18Yes681613
V742A19Yes652137
D761N19Yes1047537
S768I20Yes315250125
R776C20Yes1104736
S784F20Yes1939543
T790M20Yes>2,000>2,000>2,000
G810S20Yes965730
N826S21Yes505505348
L838V21Yes18716070
V851A21No
I853T21No
L861Q21Yes17010351
A864T21Yes754940
E866K21No
  • NOTE: Cellular IC50 values for gefitinib, erlotinib, and AEE788 for various EGFR mutants were calculated using the data from Fig. 4.