Table 2.

Toxicity hematological by administered activity and hematological by duration using CTCAE 2.0

A) By administered activity
Administered activity (MBq/m2)Haemoglobin nadir (g/dl; median/range)Neutrophil nadir (×109/liter; median/range)Platelet nadir (×109/liter; median/range)Lymphocyte nadir (×109/liter; median/range)
370 (3 treatments)9.8 (8.4-11.4)3 (2.7-3.7)187 (74-195)0.45 (0.31-0.96)
740 (6 treatments)9.5 (9-11.5)4.7 (1.3-11.3)198 (60-384)0.38 (0.19-1.55)
1,200 (5 treatments)8.8 (7.7-10.2)1.3 (0.9-7.5)31 (9-83)0.2 (0.18-1.55)
1,480 (6 treatments)8.4 (7-10)0.8 (0.1-7.8)15 (8-150)0.2 (0.1-0.58)
>2,220 (4 treatments)8.5 (6.3-9.5)1 (0.34-2.7)13 (8-36)0.105 (0.06-0.21)
B) Duration of time (in d) at ≥grade 3 or 4 until two readings are recorded for an improved grade or until a second therapy is instigated (which includes a further cycle of CHT25)
Administered activity (MBq/m2)3707401,2001,4802,2202,960
Grade 3 or 4 platelets median/range (d)Nil encounteredNil encounteredMedian, 3Median, 29.5Median, 3345 d (until patient death)
Range, 0-60Range, 0-78Range, 28-176
Grade 3 or 4 neutrophils median/range (d)Nil encounteredNil encounteredMedian, 0Median, 5.5Median, 038 d (until patient death)
Range, 0-1Range, 0-30Range, 0-1
Grade 4 neutrophils median/range (d)Nil encounteredNil encounteredNil encounteredMedian, 2Median, 044 d (until patient death)
Range, 0-30Range, 0-1