Table 2.

Dose-escalation scheme

XRP6258 dose level (mg/m2)New patients at this dose level (courses)Patients reduced to this dose level (courses)Total patients (courses)New patients with DLT
103 (10)03 (10)0
156 (24)1 (1)7 (25)1
209 (29)4 (19)13 (48)0
257 (19)0 (0)7 (19)3