Table 3.

Hematologic toxicity

Dose level (mg/m2)No. evaluable coursesNo. courses (first course) with toxicity
Neutropenia
Thrombocytopenia
Median nadir ANC (range; μL)*Grade 1-2Grade 3Grade 4Grade 4 >5 dGrade 3-4 + feverPLTs (/μL) 25,000-50,000PLTs (/μL) <25,000
10104,760 (2,980-7,790)0000000
15252,480 (880-8,500)9 (3)000000
20482,280 (260-4,270)6 (3)0 (0)00000
2519990 (30-5,090)15 (3)4 (1)8 (3)2 (2)1 (1)1 (0)0
  • Abbreviation: PLTs, platelets.

  • * Median values (ranges) for first course.