Table 3.

Associations between founder mutations in the BRCA1 and BRCA2 genes and Gleason score

Gleason score
Controls
Cases: Gleason score 2-6
Cases: Gleason score 7-10
Carrier/noncarrier
Carrier/noncarrier
Carrier/noncarrier
Mutationsn (%)*n (%)*OR (95% CI)n (%)*OR (95% CI)
BRCA1 185delAG7/1,234 (0.6)3/538 (0.6)0.99 (0.25-3.92)7/351 (1.9)3.54 (1.22-10.31)
Any BRCA1 mutation11/1,236 (0.9)4/539 (0.7)0.82 (0.26-2.64)7/351 (1.9)2.23 (0.84-5.86)
BRCA2 6174delT12/1,228 (1.0)5/534 (0.9)0.92 (0.31-2.67)11/344 (3.0)3.18 (1.37-7.34)
BRCA1 (185delAG) or BRCA2 (6174delT)19/1,230 (1.5)8/536 (1.5)0.95 (0.41-2.20)17/341 (4.8)3.18 (1.62-6.24)
Any mutations in BRCA1/BRCA223/1,227 (1.8)9/535 (1.7)0.87 (0.39-1.92)17/341 (4.8)2.61 (1.36-4.98)
  • NOTE: Missing values varied by mutation: BRCA1 185delAG (3 cases, 11 controls); BRCA1 5382insC (3 cases, 12 controls); BRCA2 6174delT (10 cases, 12 controls).

  • * Percentages of mutation carriers in each category.

  • ORs and 95% CI were generated using polytomous logistic regression; models were adjusted for age at diagnosis (cases) and age at interview (controls); Reference category is nonmutation carriers.