Table 4.

Associations between founder mutations in BRCA1 and BRCA2 and prostate cancer, stratified by first-degree family history of prostate, breast or ovarian cancers

MutationsPositive family history of prostate cancer
No family history of prostate cancer
Cases
Controls
OR* (95% CI)Cases
Controls
OR* (95% CI)
Carrier/noncarrier
Carrier/noncarrier
Carrier/noncarrier
Carrier/noncarrier
n (%)n (%)n (%)n (%)
BRCA1 185delAG2/274 (0.7)1/177 (0.6)1.61 (0.14-18.10)9/691 (1.3)6/1,057 (0.6)2.06 (0.71-5.92)
Any BRCA1 mutation2/274 (0.7)1/178 (0.6)1.60 (0.14-18.06)10/692 (1.4)10/1,058 (0.9)1.38 (0.56-3.40)
BRCA2 6174delT3/269 (1.1)1/176 (0.6)1.91 (0.20-18.60)15/682 (2.2)11/1,052 (1.0)2.10 (0.93-4.70)
BRCA1 (185delAG) or BRCA2 (6174delT)5/271 (1.8)2/176 (1.1)1.76 (0.34-9.24)23/680 (3.3)17/1,054 (1.6)2.01 (1.05-3.85)
Any mutations in BRCA1/BRCA25/271 (1.8)2/177 (1.1)1.77 (0.34-9.27)24/679 (3.4)21/1,050 (2.0)1.68 (0.91-3.09)

Mutations
Positive family history of breast or ovarian cancers
No family history of breast or ovarian cancers
Cases
Controls
OR* (95% CI)Cases
Controls
OR* (95% CI)
Carrier/noncarrier
Carrier/noncarrier
Carrier/noncarrier
Carrier/noncarrier

n (%)
n (%)

n (%)
n (%)

BRCA1 185delAG4/185 (2.1)4/219 (1.8)1.01 (0.24-4.28)7/780 (0.9)3/1,015 (0.3)3.45 (0.86-13.63)
Any BRCA1 mutation4/186 (2.1)5/219 (2.2)0.86 (0.22-3.38)8/780 (1.0)6/1,017 (0.6)1.81 (0.61-5.36)
BRCA2 6174delT7/182 (3.7)7/214 (3.2)1.04 (0.35-3.10)11/769 (1.4)5/1,014 (0.5)3.16 (1.07-9.29)
BRCA1 (185delAG) or BRCA2 (6174delT)10/180 (5.3)11/213 (4.9)0.93 (0.37-2.29)18/771 (2.3)8/1,017 (0.8)3.30 (1.41-7.73)
Any mutations in BRCA1/BRCA210/180 (5.3)12/212 (5.4)0.87 (0.36-2.11)19/770 (2.4)11/1,015 (1.1)2.44 (1.14-5.22)
  • NOTE: Missing values varied by mutation: BRCA1 185delAG (3 cases, 11 controls); BRCA1 5382insC (3 cases, 12 controls); BRCA2 6174delT (10 cases, 12 controls).

  • * ORs are adjusted for age at diagnosis (cases) and age at interview (controls); Reference category is nonmutation carriers.

  • Percentages of mutation carriers in each category.

  • P = 0.04 for interaction between mutation carrier status and family history of breast/ovarian cancer. Other P values for interaction analysis between mutation carrier status and family history of either prostate, or breast or ovarian cancers were not statistically significant.