Table 2.

Univariate analyses of prognosis factors associated with survival

VariablesDFS
OS
Cancer-specific survival
HR (95% CI)PHR (95% CI)PHR (95% CI)P
Age, y (≤52 vs >52)0.78 (0.53-1.15)0.210.80 (0.53-1.21)0.290.98 (0.54-1.80)0.95
Gender (female vs male)0.69 (0.38-1.26)0.220.70 (0.37-1.31)0.270.57 (0.20-1.59)0.28
Hepatitis history (no vs yes)0.76 (0.40-1.46)0.421.26 (0.55-2.90)0.580.88 (0.31-2.48)0.80
α-Fetoprotein, ng/mL (≤20 vs >20)1.70 (1.14-2.53)0.00952.08 (1.37-3.15)0.00052.27 (1.11-4.66)0.025
γ-Glutamyl transferase, units/L (≤54 vs >54)1.63 (1.08-2.44)0.0192.04 (1.32-3.17)0.00152.31 (1.18-4.52)0.015
Liver cirrhosis (no vs yes)1.35 (0.72-2.53)0.342.13 (0.99-4.62)0.0551.71 (0.61-4.81)0.31
Tumor differentiation (well vs poor)1.50 (1.02-2.21)0.0411.85 (1.22-2.78)0.00352.05 (1.11-3.80)0.023
Tumor size, cm (≤5 vs >5)2.46 (1.63-3.71)<0.00012.60 (1.68-4.02)<0.00011.97 (1.06-3.69)0.033
Tumor multiplicity (single vs multiple)2.37 (1.57-3.58)<0.00011.82 (1.17-2.83)0.0082.62 (1.39-4.94)0.003
Tumor encapsulation (complete vs none)2.51 (1.66-3.80)<0.00011.67 (1.10-2.53)0.0161.73 (0.93-3.23)0.08
Vascular invasion (no vs yes)4.60 (3.01-7.03)<0.00014.78 (3.03-7.55)<0.00014.10 (2.12-7.92)<0.0001
TNM stage (I vs II vs III)2.96 (2.29-3.83)<0.00012.90 (2.21-3.80)<0.00013.38 (2.22-5.14)<0.0001
FoxP3+ TILs (low vs high)2.09 (1.41-3.12)0.00032.79 (1.81-4.30)<0.00013.33 (1.72-6.44)0.0004
Granzyme B+ TILs (low vs high)0.49 (0.33-0.74)0.00060.49 (0.32-0.74)0.00080.43 (0.23-0.80)0.008
PD-L1 (low vs high)1.79 (1.18-2.70)0.00581.61 (1.04-2.50)0.0321.24 (0.62-2.48)0.54
PD-L2 (low vs high)1.45 (0.93-2.24)0.0991.60 (1.01-2.52)0.0441.09 (0.52-2.28)0.82
Combined PD-Ls*
    OverallNA0.0007NA0.0019NA0.64
    I vs II1.42 (0.94-2.14)0.0961.41 (0.92-2.18)0.121.33 (0.72-2.47)0.37
    I vs III3.72 (1.87-7.39)0.00023.61 (1.75-7.41)0.00050.83 (0.11-6.15)0.85
  • NOTE: Cox proportional hazards regression model.

    Abbreviation: NA, not applicable.

  • * Patients were divided into three groups: (a) both PD-L1 and PD-L2 were positive (n = 13), (b) either PD-L1 or PD-L2 was positive (n = 94), and (c) both PD-L1 and PD-L2 were negative (n = 133).