Table 3.

List of genes most significantly down-regulated after seliciclib treatment (P < 0.02)

GenePGene IDFunction
MAPKAPK20.009261Signal transduction/MAPK signaling
BID0.001637Proapoptotic
TYMS0.0027298DNA synthesis
RPLP00.0026175Ribosomal protein
BTRC0.0028945Signal transduction(รข-catenin and NF-kB)/transformation
XPC0.0027508DNA repair
HSPA80.0033312MAPK signaling pathway and cellular macromolecule metabolism
CDK70.0031022Cell cycle and transcriptional regulation
TBP0.0036908Transcription factor/regulates RNA pol II activity
PIK3C1/PIK3CB0.005291Signal transduction and transformation
ORC6L0.00323594DNA replication and cell cycle
GADD45A0.0041647Signal transduction/p38-JNK activation
MAPK3/ERK10.0045595signal transduction/MAPK signaling/apoptosis/cell proliferation
ORC5L0.005001DNA replication
MCM30.0054172DNA replication - eukaryotic gene replication initiation
ACBD30.0164746signal transduction
GTF3C40.0059329Transcription factor/RNA pol III activity
RAF10.0055894signal transduction/cell proliferation/interacts with PAKs/MEKs/ERKs
SIRT2/Sir20.00523411Antiapoptotic (negatively regulates p53 function)
MAP4K1/HPK10.00611184Signal transduction/MAPK/JNK signaling/apoptosis
SHP2/PTPN110.0065781Signal transduction/JAK Stat signaling
eIF2A0.0183939Translation initiation
JMJ/JARID20.0063720Cell proliferation repression
RAB5A0.0075868Signal transduction/cell proliferation
UBE2N0.0077334DNA repair
pNUTS/PPP1R100.0075514
BCL2L11/BIM0.00710018Proapoptotic
MAP2K5/MEK50.0075607Signal transduction/MAPK signaling and antiapoptosis
GATA20.0082624Transcription factor binding
TNFRSF6/FAS0.008355MAPK signaling pathway/apoptosis
ERCC60.0082074DNA repair
CDC420.008998MAPK signaling(interacts with PAKs)/cell proliferation
HEAB0.00910978RNA metabolism/ATP GTP binding protein
DVL10.011855Signal transduction/b-catenin WNT signaling
SMAD40.014089Cell cycle and signal transduction of WNT and TGF? family
DCTD0.011635Nucleotide metabolism
CYC10.011537Proapoptotic
CASP100.011843Effector of apoptosis
GRB20.0112885MAPK signaling pathway
MAP2K6/MKK60.0115608MAPK signaling pathway
HIST4H40.012121504DNA binding and metabolism
BCL20.012596Antiapoptosis
STAT10.0136772Signal transduction
MAPK14/p380.0131432MAPK signaling pathway
ERCC40.0132072DNA repair and metabolism
MAX0.0134149MAPK signaling pathway
EP3000.012033Transcriptional factor/transcription coactivation
MAPK1/ERK0.0135594MAPK signaling pathway/apoptosis
APC0.014324Signal transduction/WNT signaling pathway
MAPK4K40.0159448MAPK signaling pathway
CRK0.0151398MAPK signaling pathway
FADS10.023992Cellular metabolism
PRKACG0.0155568MAPK signaling/aopotosis
ELK4/SAP10.0172005MAPK signaling and cellular metabolism
PAK20.0175062MAPK signaling pathway
IKBKB0.0173551MAPK signaling pathway and apoptosis
TP530.0187157Cell cycle regulation and MAPK signaling pathway
AGTPBP10.01823287Cellular metabolism
MSK-1/RPS6KA50.0189252MAPK signaling pathway
BCL11A0.01853335Cellular metabolism
MAP3K6/ASK20.0189064MAPK signaling pathway/JNK signaling
TRAF50.0197186MAPK signaling pathway/apoptosis