Table 1.

Tumor growth ability

A. Tumor growth of carcinoma HER2-High and HER2-Low cells at different dilutions
Cell lineHER2 levelsOutgrowths/injections
106 injected cells105 injected cells104 injected cells
MDA-MB-361HER2-High6/64/63/6
HER2-Low6/64/60/6
SKOV-3HER2-High6/66/64/6
HER2-Low6/65/60/6
B. Serial transplantability of untreated or drug-treated xenotransplants
Cell lineTreatmentOutgrowths/injections
1° passage (106 injected cells)2° passage (105 injected cells)3° passage (105 injected cells)
MDA-MB-361NT5/53/52/4
Doxorubicin5/54/53/4
Trastuzumab3/50/5-
SKOV-3NT5/54/53/5
Doxorubicin5/54/53/5
Trastuzumab3/50/5-
MCF7NT5/55/55/5
Doxorubicin5/55/55/5
Trastuzumab5/55/55/5
  • Abbreviation: NT, untreated.