Table 2.

Characteristics of the 15 high-risk individuals from the CAPS 1 (20) and CAPS 2 (19) studies for whom a definitive diagnosis was obtained after the discovery of abnormal findings at screening or during surveillance

PatientUnderlying conditionNo. relatives with pancreatic cancerPancreatic neoplastic-type lesion and FNA resultsSurgeryPathology
1FPC7Head: 2.1 cm mass by EUS; EUS-FNA: not donePancreaticoduodenectomyT2N1 adenocarcinoma, PanIN 1 and 2 at margin
2PJS0Uncinate: 2.0 cm mass by EUS and CT; EUS-FNA: not donePancreaticoduodenectomyBorderline IPMN; diffuse PanIN 1 and 2
3FPC2Head: 1.5 cm cystic mass by EUS and CT; EUS-FNA: benign pancreatic cells in a mucinous backgroundPancreaticoduodenectomyBenign serous multiloculated cystadenoma
4FPC3Head: 1.3 cm cystic mass by EUS and CT; EUS-FNA: nondiagnosticPancreaticoduodenectomyBenign serous multiloculated cystadenoma; focal PanIN 1
5FPC4Tail: 1.0 cm mass by EUS and CT EUS-FNA: ectopic spleen by positive specific immunocytochemical stainingDistal pancreatectomyDiffuse PanIN 1 and 2; ectopic spleen; 0.5 cm microcystic serous cystadenoma
6FPC6Body: 1.6 cm mass by EUS EUS-FNA: nondiagnosticDistal pancreatectomyDiffuse, multiple, PanIN 1-3; pancreatic abscess; mild focal acute and chronic pancreatitis
7FPC3Dysplasia in random EUS-FNADistal pancreatectomyDiffuse PanIN 1A and 1B; mild focal acute and chronic pancreatitis
8PJS0Uncinate: 1.5 cm cyst by EUS and CT; EUS-FNA: not donePylorus-sparing pancreaticoduodenectomyBranch-type IPMN with carcinoma in situ
9FPC3Tail: 1.4 and 1.1 cm cysts by EUS and CT: EUS-FNA: mucinous ductal epithelium suspicious for IPMNDistal pancreatectomyTwo branch-type IPMN-adenomas; multifocal PanIN 1-3 with possible focus of microinvasive adenocarcinoma
10FPC3Head and body: 9 and 10 mm focal cystic dilation of main pancreatic duct by EUS* EUS-FNA: mucinous ductal epithelium suspicious for IPMNExtended pylorus-sparing pancreaticoduodenectomyIncipient IPMN
11FPC4Tail: 1 cm hypoechoic nodule by EUS; EUS-FNA: atypical, neoplastic-type pancreatic ductal epithelium (repeated twice)Distal pancreatectomyFocal fibrosis, atrophy; diffuse multiple foci of PanIN 1 and 2
12FPC3Head: 1.5 cm cyst by EUS and CT; EUS-FNA: mucinous ductal epithelium suspicious for IPMNPylorus-sparing pancreaticoduodenectomyTwo branch-type IPMN adenomas; diffuse PanIN 1 and 2; multifocal chronic pancreatitis
13FPC3Head: 1.4 cm cyst by EUS; EUS-FNA: not donePylorus-sparing pancreaticoduodenectomyBranch-type IPMN adenoma; multifocal PanIN 1A and 2 associated with focal fibrosis and atrophy
14FPC5Uncinate: 6 mm cyst, which enlarged to 9 mm after 3 mo by EUS and CT; EUS-FNA: not doneNo surgeryAdenocarcinoma at percutaneous biopsy of liver and pancreatic masses
15FPC5Head: 6 mm cyst with mural nodule by EUS; EUS-FNA: mucinous ductal epithelium with cellular atypiaPylorus-sparing pancreaticoduodenectomyBranch-type IPMN adenoma; diffuse PanIN 1 and 2; multifocal diffuse chronic pancreatitis
  • * A 6 mm cyst in the body was seen at CT.

  • The two cystic lesions identified preoperatively could not be identified in the resected specimen because of processing problems.

  • Lesions were detected during surveillance.