Table 3.

Breast cancer risks associated with prostaglandin tagSNPs examined

Gene and SNPs*MAFOR (95% CI) (heterozygotes vs common homozygotes)OR (95% CI) (rare homozygotes vs common homozygotes)HeterogeneityTrend test
P (2 df)P (1 df)
PTGS1
    rs1330344(01)0.210.92 (0.81-1.05)1.01 (0.77-1.33)0.470.44
    rs10306122(04)0.070.98 (0.82-1.18)0.93 (0.38-2.30)0.970.83
    rs10306194(05)0.160.90 (0.79-1.03)0.93 (0.63-1.39)0.30.15
    rs4836887(07)0.130.93 (0.81-1.06)0.96 (0.59-1.58)0.560.31
    rs10306108(08)0.071.03 (0.87-1.22)0.97 (0.44-2.12)0.90.77
    rs10306146(15)0.130.92 (0.80-1.06)0.98 (0.58-1.67)0.490.28
PTGS2
    rs4648310(01)0.040.80 (0.62-1.02)1.03 (0.26-4.11)0.20.1
    rs689467(02)0.071.09 (0.92-1.29)1.29 (0.53-3.11)0.550.28
    rs2206593(03)0.051.05 (0.86-1.27)2.27 (0.86-5.98)0.210.28
    rs5275(04)0.341.05 (0.92-1.19)1.08 (0.89-1.31)0.660.36
    rs5277(09) set 1 only0.160.85 (0.75-0.98)0.90 (0.61-1.33)0.070.03
    rs5277(09)0.160.95 (0.87-1.05)1.13 (0.86-1.50)0.370.71
    rs20424(11)0.020.84 (0.61-1.15)1.03 (0.00-1.13)0.540.27
    rs4648276(17)0.120.98 (0.85-1.14)1.16 (0.73-1.84)0.790.91
PTGIS
    rs6090990(03)0.251.02 (0.90-1.15)1.05 (0.82-1.35)0.90.66
    rs5602(04) set 1 only0.490.87 (0.75-1.00)1.06 (0.90-1.25)0.010.55
    rs5602(04)0.490.98 (0.88-1.08)1.14 (1.01-1.28)0.020.04
    rs6090996(05) set 1 only0.210.81 (0.71-0.92)1.08 (0.80-1.45)0.0040.04
    rs6090996(05)0.210.91 (0.83-0.99)1.04 (0.85-1.29)0.070.18
    rs508757(06)0.20.96 (0.84-1.09)1.11 (0.82-1.49)0.620.95
    rs707528(08)0.490.93 (0.80-1.07)1.06 (0.90-1.25)0.170.49
    rs477627(11) set 1 only§0.161.05 (0.92-1.20)0.61 (0.41-0.91)0.030.47
    rs477627(11)§0.161.03 (0.94-1.14)0.66 (0.50-0.87)0.010.3
    rs693649(12)0.20.92 (0.81-1.04)0.88 (0.64-1.19)0.340.15
    rs6012696(13)0.071.07 (0.90-1.27)1.15 (0.49-2.72)0.70.4
    rs556731(14) set 1 only0.050.74 (0.60-0.92)0.51 (0.13-2.03)0.020.003
    rs556731(14)0.050.92 (0.79-1.06)1.22 (0.55-2.74)0.450.36
    rs6095543(15)0.161.05 (0.92-1.19)1.37 (0.95-1.96)0.20.15
    rs1393343(16)0.220.89 (0.78-1.01)1.14 (0.87-1.50)0.080.48
    rs574113(17)0.340.97 (0.86-1.10)1.04 (0.86-1.26)0.760.92
    rs501908(18)0.11.07 (0.93-1.25)0.98 (0.58-1.67)0.640.43
    rs8183919(19) set 1 only0.290.99 (0.87-1.12)1.28 (1.03-1.58)0.050.14
    rs8183919(19)0.291.01 (0.93-1.10)1.23 (1.06-1.43)0.020.04
    rs1066894(20)0.310.91 (0.80-1.03)0.95 (0.78-1.17)0.350.28
    rs476496(21)0.241.00 (0.88-1.13)1.03 (0.80-1.33)0.970.92
PTGES
    rs2302821(03)0.080.86 (0.73-1.01)1.19 (0.55-2.57)0.170.14
    rs4837404(04)0.350.98 (0.86-1.11)1.02 (0.84-1.23)0.890.99
    rs10739757(05)0.11.05 (0.91-1.22)1.62 (0.87-2.99)0.250.21
    rs10448290(06) set 1 only0.091.00 (0.85-1.17)2.92 (1.36-6.28)0.020.27
    rs10448290(06)0.091.01 (0.91-1.14)1.78 (1.09-2.90)0.060.24
    rs12553596(13)0.071.02 (0.86-1.21)2.96 (1.16-7.52)0.060.27
PTGDS
    rs11787588(01)0.270.9 (0.8-1.0)0.8 (0.7-1.1)0.320.13
    rs10781530(03)0.311.1 (1.0-1.2)1.0 (0.8-1.2)0.310.44
    rs908839(04)0.471.0 (0.9-1.2)1.1 (0.9-1.3)0.630.38
PGDS
    rs10516950(02)0.441.00 (0.88-1.15)1.05 (0.89-1.25)0.820.6
    rs1045435(03)0.390.91 (0.80-1.03)0.8 9 (0.74-1.06)0.240.11
TBXAS1
    rs6971207(01)0.011.24 (0.84-1.81)209.5 (0.0-7155E)0.20.15
    rs2267681(02)0.420.97 (0.85-1.11)0.92 (0.77-1.09)0.620.34
    rs7810415(03)§,0.480.94 (0.82-1.09)1.09 (0.92-1.29)0.140.34
    rs3779134(04)0.121.05 (0.91-1.22)1.05 (0.67-1.67)0.780.49
    rs194149(05)0.281.04 (0.91-1.17)0.93 (0.75-1.16)0.630.9
    rs11973494(08)0.220.90 (0.79-1.02)0.93 (0.71-1.22)0.260.16
    rs2284205(09)0.161.03 (0.90-1.18)0.87 (0.60-1.25)0.650.96
    rs2107901(11)0.170.94 (0.82-1.07)1.08 (0.76-1.53)0.570.64
    rs10487665(12)0.090.96 (0.82-1.13)1.10 (0.54-2.23)0.850.73
    rs2190087(13)0.231.04 (0.92-1.17)1.03 (0.79-1.35)0.850.61
    rs1557967(14)0.20.99 (0.87-1.13)1.13 (0.83-1.53)0.720.72
    rs1003816(15)0.11.01 (0.87-1.18)1.89 (1.09-3.28)0.070.23
    rs41728(16)0.120.97 (0.84-1.12)1.77 (1.08-2.88)0.060.44
    rs41727(17) set 1 only0.10.96 (0.82-1.12)3.71 (1.77-7.80)0.00080.3
    rs41727(17)0.11.0 1 (0.91-1.13)1.83 (1.23-2.74)0.010.12
    rs2267701(20)0.140.99 (0.86-1.14)1.58 (1.00-2.50)0.140.42
    rs740150(21)0.191.10 (0.97-1.26)0.88 (0.65-1.21)0.190.5
    rs10487667(23)0.251.12 (0.99-1.27)1.05 (0.83-1.33)0.20.16
    rs2267706(25)0.231.07 (0.94-1.21)1.07 (0.82-1.40)0.550.31
    rs22861987(28)0.381.13 (1.00-1.29)1.11 (0.93-1.34)0.150.11
    rs2286196(29)0.191.06 (0.93-1.21)0.85 (0.62-1.17)0.360.89
    rs2267692(30)0.351.02 (0.90-1.16)1.07 (0.89-1.29)0.750.47
    rs1015572(31)0.051.00 (0.82-1.23)0.52 (0.16-1.72)0.550.75
    rs1015570(32)0.391.09 (0.96-1.24)1.03 (0.86-1.23)0.430.5
    rs2299887(37)0.41.04 (0.91-1.19)1.00 (0.84-1.19)0.810.84
    rs10544451(38)0.241.02 (0.90-1.16)1.07 (0.82-1.39)0.860.59
  • NOTE: Bold italic: results significant at P < 0.05 or P = 0.05 in the combined data for sets 1 and 2 (4,470 cases and 4,560 controls).

  • * All genes assessed in set 1 (2,270 cases and 2,280 controls) only, unless in bold text.

  • MAF is among controls in set 1.

  • SNPs in bold text were taken through into set 2. Results refer to the combined data for sets 1 and 2 unless specified.

  • § Controls are out of Hardy-Weinberg.

  • Multi-SNP haplotypes used to increase tagging efficiency.