Table 4.

Global haplotype analysis of tagSNPs

Gene*HaplotypeFrequencyPOR (95% CI)§Global P
PTGS1h0000000.530.120.54
08, 01, 04, 15, 07, 05h0000010.150.09
h0001100.090.79
h0100000.060.34
h0110000.040.55
h1100000.070.77
Combined rare0.050.72
PTGS2h00000000.440.990.55
01, 02, 03, 04, 17, 09, 11h00000100.110.36
h00010000.150.77
h00011000.120.9
h00100000.050.27
h01010000.070.31
h10000100.030.1
Combined rare0.020.6
PTGISh0000000.120.190.06
block 1: 14, 15, 03, 16, 17, 04h0000010.020.4
h0000100.340.94
h0001010.220.45
h0010010.090.33
h0110010.160.15
h1000000.030.33
Combined rare0.020.010.65 (0.48-0.89)
PTGIS block 2: 05, 06, 08, 18, 19, 20, 21, 11, 12, 13h00000000000.050.950.01
h00000000100.050.34
h00000011000.040.041.28 (1.01-1.63)
h00000100000.040.37
h00000111000.030.0050.65 (0.48-0.88)
h00100000000.040.030.74 (0.56-0.96)
h00100100000.070.23
h00100111000.020.24
h00101000000.140.031.16 (1.02-1.32)
h00101000010.020.52
h00101000100.050.89
h00101010000.040.34
h11000000000.030.16
h11000000100.030.85
h11010100000.030.81
Combined rare0.330.25
PTGESh000000.520.570.44
03, 13, 04, 05, 06h000100.030.47
h001000.290.6
h010110.060.1
h100000.030.38
h101000.040.32
Combined rare0.040.27
PTGDSH0000.030.980.74
04, 01, 03h0010.230.51
h0100.260.11
h1000.40.49
h1010.070.66
Combined rare0.010.73
PGDSh000.180.220.42
02, 03h010.380.13
h100.430.58
Combined rare0.010.99
TBXAS1 block 1: 01, 02, 03, 04, 05, 37, 31, 32, 30, 08, 09, 11, 12h00000000000000.240.720.4
h00000000000100.040.54
h00000000111010.050.23
h00100000000000.020.06
h00100101100000.060.12
h01000000000000.050.34
h01100000000000.090.59
h01111101000000.080.97
Combined rare0.360.81
TBXAS1h00000000.570.660.28
block 2: 38, 13, 14, 15, 16, 17, 20h00000010.090.19
h00100000.050.5
h00100010.040.78
h11000000.110.92
h11111100.090.17
Combined rare0.050.06
TBXAS1h000000.430.310.4
block 3: 21, 23, 25, 28, 29h000100.10.57
h000110.060.85
h001000.040.3
h001110.070.46
h010000.030.61
h011110.030.07
h110000.070.42
h110100.020.22
h111110.020.98
Combined rare0.140.1
  • * SNPs used for haplotype analysis are arranged in chromosome order: 0, major allele; 1, minor allele.

  • All genes assessed in set 1 (2,270 cases and 2,280 controls) only.

  • The baseline for each test is the frequency of all the other haplotypes combined.

  • § OR (95% CI) given for haplotypes showing a difference between cases and controls at a significance level of P ≤ 0.05.

  • See Table 3 for study assay numbers and their related rs numbers.

  • Rare haplotypes (≤5%) were pooled.