Table 5.

Prostaglandin tagSNP survival analysis

Gene/SNP*MAFPtrendHazard ratio per allele (95% CI)PheterogeneityHeterozygote risk (95% CI)Homozygote risk (95% CI)
PTGDS
    PTGDS(01)rs117875880.270.921.01 (0.85-1.20)0.291.13 (0.90-1.40)0.79 (0.48-1.30)
    PTGDS(03)rs107815300.310.431.07 (0.91-1.25)0.61.01 (0.81-1.27)1.2 (0.85-1.71)
    PTGDS(04)rs9088390.470.680.97 (0.83-1.13)0.730.9 (0.70-1.16)0.95 (0.70-1.27)
PTGES
    PTGES(03)rs23028210.080.081.27 (0.98-1.65)0.111.18 (0.87-1.58)2.61 (1.08-6.33)
    PTGES(04)rs48374040.350.510.95 (0.81-1.11)0.720.91 (0.73-1.14)0.93 (0.66-1.31)
    PTGES(05)rs107397570.10.270.87 (0.68-1.12)0.530.89 (0.68-1.17)0.66 (0.21-2.05)
    PTGES(06)rs104482900.090.060.77 (0.58-1.02)0.070.84 (0.62-1.13)0.22 (0.03-1.57)
    PTGES(13)rs12553596 (set 1)0.070.040.73 (0.53-1.00)0.10.76 (0.54-1.06)0.32 (0.05-2.26)
    PTGES(13)rs12553596 (set 1 and 2 combined)0.070.070.81 (0.65-1.02)0.190.82 (0.64-1.05)0.6 (0.19-1.88)
PTGIS
    PTGIS(03)rs60909900.250.710.97 (0.81-1.15)0.860.94 (0.75-1.18)0.99 (0.64-1.53)
    PTGIS(04)rs56020.490.860.99 (0.85-1.14)0.141.23 (0.94-1.60)0.98 (0.72-1.33)
    PTGIS(05)rs60909960.210.560.95 (0.78-1.14)0.840.96 (0.75-1.21)0.87 (0.51-1.50)
    PTGIS(06)rs5087570.20.261.11 (0.93-1.33)0.531.12 (0.89-1.41)1.2 (0.73-1.96)
    PTGIS(08)rs7075280.490.911.01 (0.87-1.17)0.760.93 (0.72-1.21)1.02 (0.76-1.36)
    PTGIS(11)rs4776270.160.511.07 (0.87-1.32)0.761.05 (0.83-1.33)1.28 (0.63-2.59)
    PTGIS(12)rs6936490.20.381.09 (0.9-1.31)0.331 (0.79-1.26)1.47 (0.91-2.37)
    PTGIS(13)rs60126960.070.940.99 (0.74-1.32)0.950.97 (0.71-1.32)1.22 (0.30-4.89)
    PTGIS(14)rs5567310.050.20.75 (0.48-1.17)
    PTGIS(15)rs60955430.160.680.96 (0.79-1.17)0.240.85 (0.66-1.09)1.22 (0.77-2.18)
    PTGIS(16)rs13933430.220.281.1 (0.93-1.31)0.511.14 (0.91-1.42)1.14 (0.72-1.81)
    PTGIS(17)rs5741130.340.311.08 (0.93-1.26)0.231.22 (0.97-1.53)1.07 (0.76-1.51)
    PTGIS(18)rs5019080.10.441.1 (0.87-1.38)0.741.09 (0.84-1.42)1.24 (0.51-3.01)
    PTGIS(19)rs81839190.290.881.01 (0.86-1.19)0.981.02 (0.82-1.28)1.01 (0.70-1.46)
    PTGIS(20)rs10668940.310.811.02 (0.87-1.20)0.971.02 (0.82-1.28)1.04 (0.72-1.49)
    PTGIS(21)rs4764960.240.771.03 (0.86-1.22)0.740.97 (0.77-1.22)1.16 (0.76-1.79)
PTGS1
    PTGS1(01)rs13303440.210.351.09 (0.91-1.3)0.361.18 (0.94-1.47)1 (0.61-1.63)
    PTGS1(04)rs103061220.070.20.81 (0.58-1.12)
    PTGS1(05)rs103061940.160.740.96 (0.78-1.20)0.870.99 (0.77-1.27)0.81 (0.36-1.82)
    PTGS1(07)rs48368870.130.190.86 (0.68-1.09)0.380.88 (0.68-1.14)0.57 (0.18-1.77)
    PTGS1(08)rs103061080.070.591.08 (0.82-1.42)0.471.15 (0.86-1.54)0.49 (0.07-3.47)
    PTGS1(15)rs103061460.130.140.84 (0.65-1.07)0.340.84 (0.64-1.10)0.66 (0.21-2.06)
PTGS2
    PTGS2(01)rs46483100.040.891.03 (0.67-1.58)
    PTGS2(02)rs6894670.070.550.91 (0.68-1.23)0.750.94 (0.68-1.28)0.56 (0.08-3.98)
    PTGS2(03)rs22065930.050.431.13 (0.84-1.51)
    PTGS2(04)rs52750.340.521.05 (0.90-1.23)0.551.13 (0.9-1.42)1.04 (0.73-1.48)
    PTGS2(09)rs52770.160.791.03 (0.84-1.26)0.771.07 (0.84-1.37)0.86 (0.41-1.83)
    PTGS2(11)rs20424 (set 1)0.020.050.41 (0.17-0.99)
    PTGS2(11)rs20424 (set 1 and 2 combined)0.020.270.75 (0.45-1.25)
    PTGS2(17)rs46482760.120.061.23 (1.00-1.52)0.131.29 (1.01-1.64)1.26 (0.59-2.67)
PGDS
    PGDS(02)rs105169500.440.541.05 (0.90-1.22)0.590.97 (0.76-1.24)1.12 (0.83-1.50)
    PGDS(03)rs10454350.390.960.7 (0.86-1.16)0.981.01 (0.80-1.27)0.98 (0.71-1.36)
TBXAS1
    TBXAS1(01)rs69712070.010.71.12 (0.63-2.00)
    TBXAS1(02)rs2267681 (set 1)0.420.151.12 (0.96-1.30)0.021.4 (1.10-1.78)1.16 (0.83-1.61)
    TBXAS1(02)rs2267681 (set 1 and 2 combined)0.420.151.09 (0.97-1.21)0.111.21 (1.01-1.46)1.14 (0.90-1.44)
    TBXAS1(03)rs78104150.480.971 (0.86-1.16)0.911.05 (0.81-1.35)0.99 (0.73-1.35)
    TBXAS1(04)rs37791340.120.521.08 (0.86-1.34)0.411.16 (0.90-1.48)0.73 (0.27-1.96)
    TBXAS1(05)rs1941490.280.331.09 (0.92-1.28)0.291.19 (0.96-1.49)1.02 (0.67-1.55)
    TBXAS1(08)rs119734940.220.191.13 (0.95-1.34)0.131 (0.80-1.27)1.56 (1.03-2.36)
    TBXAS1(09)rs22842050.160.221.14 (0.93-1.39)0.21.04 (0.82-1.32)1.74 (1.00-3.04)
    TBXAS1(11)rs21079010.170.311.11 (0.91-1.34)0.591.1 (0.86-1.39)1.26 (0.72-2.21)
    TBXAS1(12)rs104876650.090.571.08 (0.83-1.39)0.841.07 (0.82-1.41)1.27 (0.41-3.96)
    TBXAS1(13)rs21900870.230.631.04 (0.88-1.25)0.561.11 (0.89-1.39)0.93 (0.56-1.54)
    TBXAS1(14)rs15579670.20.991 (0.83-1.20)0.981.01 (0.81-1.27)0.96 (0.56-1.65)
    TBXAS1(15)rs10038160.10.811.03 (0.82-1.30)0.891 (0.76-1.32)1.21 (0.57-2.56)
    TBXAS1(16)rs417280.120.641.05 (0.85-1.31)0.871.07 (0.83-1.39)1.03 (0.48-2.17)
    TBXAS1(17)rs417270.10.821.03 (0.81-1.31)0.70.97 (0.73-1.28)1.38 (0.65-2.92)
    TBXAS1(20)rs22677010.140.931.01 (0.82-1.25)0.720.96 (0.74-1.23)1.28 (0.66-2.49)
    TBXAS1(21)rs7401500.190.550.94 (0.78-1.14)0.571 (0.79-1.25)0.71 (0.37-1.39)
    TBXAS1(23)rs104876670.250.41.08 (0.91-1.27)0.681.09 (0.87-1.36)1.13 (0.75-1.71)
    TBXAS1(25)rs22677060.230.81.02 (0.86-1.22)0.431.12 (0.90-1.39)0.85 (0.51-1.41)
    TBXAS1(28)rs228619870.380.151.12 (0.96-1.31)0.11.3 (1.02-1.65)1.18 (0.84-1.64)
    TBXAS1(29)rs22861960.190.411.08 (0.90-1.31)0.211.19 (0.96-1.49)0.8 (0.41-1.56)
    TBXAS1(30)rs22676920.350.161.12 (0.96-1.30)0.351.08 (0.85-1.36)1.27 (0.92-1.73)
    TBXAS1(31)rs10155720.050.911.02 (0.72-1.45)0.890.99 (0.69-1.44)1.7 (0.24-12.13)
    TBXAS1(32)rs10155700.390.490.95 (0.81-1.11)0.270.83 (0.66-1.05)0.96 (0.71-1.32)
    TBXAS1(37)rs22998870.40.720.97 (0.83-1.13)0.420.87 (0.69-1.10)1 (0.74-1.36)
    TBXAS1(38)rs105444510.240.481.07 (0.90-1.27)0.541.13 (0.91-1.41)0.99 (0.61-1.61)
  • NOTE: Bold italic: significant at P < 0.05 or P = 0.05 for either Ptrend or Pheterogeneity results show combined sets 1 and 2 data (4,470 cases and 4,560 controls).

  • * All genes assessed in set 1 (2,270 cases and 2,280 controls) only, unless P ≤ 0.05 for either Ptrend or Pheterogeneity; see bold italic areas.

  • Values for these SNPs have been calculated individually due to their low frequency.