Table 2.

Brain concentrations and relative brain accumulation after oral (10 mg/kg) or i.p. (5 mg/kg) administration of dasatinib

Strain
WTAbcb1a/1b−/−Abcg2−/−Abcb1a/1b;Abcg2−/−
Oral
    Cbrain (ng/g)6.50 ± 2.1037.2 ± 5.38*4.93 ± 1.13171.6 ± 30.9*
    Pbrain (×10−3 h−1)6.39 ± 1.3922.7 ± 5.41*5.11 ± 0.6884.3 ± 13.3*
I.p.
    Cbrain (ng/g)5.47 ± 0.3825.6 ± 3.56*5.15 ± 1.73116.7 ± 15.2*
    Pbrain (×10−3 h−1)3.44 ± 0.1716.4 ± 1.71*2.78 ± 0.6578.1 ± 18.8*
  • NOTE: Data are means ± SD, n = 5 for oral and n = 4 for i.p. administration. All parameters obtained for KO mice were compared with those for WT mice.

    Abbreviations: Cbrain, brain concentration at 6 h after administration; Pbrain, relative brain accumulation at 6 h after administration, calculated by determining the dasatinib brain concentration relative to AUC0-6.

  • * P < 0.001, compared with WT mice.