Table 3.

Association between p53 codon 72 phenotypes and clinic pathologic characteristics

VariableAfrican Americans (n = 137)
Caucasians (n = 236)
Arg/Arg
Arg/Pro
Pro/Pro
χ2 PArg/Arg
Arg/Pro
Pro/Pro
χ2 P
26 (19%)87 (64%)24 (17%)85 (36%)134 (57%)17 (7%)
Age group (y)
    <659 (35)35 (40)12 (50)0.53135 (40)65 (49)2 (12)0.014
    ≥6517 (65)52 (60)12 (50)50 (60)69 (51)15 (88)
Gender
    Female14 (53)37 (43)9 (38)0.57037 (44)39 (29)10 (59)0.013
    Male12 (47)50 (57)15 (62)48 (56)95 (71)7 (41)
Tumor location*
    Proximal colon17 (65)46 (53)17 (71)0.34241 (49)50 (37)2 (12)0.012
    Distal colon5 (19)31 (36)5 (20)27 (32)48 (36)12 (71)
    Rectum4 (16)10 (12)2 (11)16 (19)36 (27)3 (18)
Nodal status*
    N011 (44)54 (62)8 (32)0.01743 (52)76 (57)12 (70)0.354
    N1-314 (56)33 (38)17 (68)40 (48)57 (43)5 (30)
Tumor grade*
    Low17 (68)71 (82)15 (63)0.09356 (68)112 (85)11 (73)0.012
    High8 (32)16 (18)9 (37)27 (32)20 (15)4 (27)
p53 status
    Wild-type11 (42)51 (59)7 (29)0.02533 (34)65 (49)11 (65)0.112
    Mutated15 (58)36 (41)17 (71)52 (66)69 (51)6 (35)
p53 mutation type
    Disruptive5 (33)16 (44)10 (59)0.34525 (48)24 (35)2 (33)0.317
    Nondisruptive10 (67)20 (56)7 (31)27 (52)45 (65)4 (67)
  • * Information on some cases was not available.

  • p53 mutation that introduces an amino acid that disrupts functional domains of p53.