Table 5.

Cox regression analysis to determine prognostic significance of p53 codon 72 phenotypes

Prognostic variablesIndicator of poor prognosisHazard ratio* (95% confidence intervals)P
African American patients
Codon 72 polymorphism
    Pro/Pro vs. Arg/Arg or Arg/ProPro/Pro2.15 (1.02-4.53)0.045
p53 status
    Mutated vs. wild-typeMutated2.30 (1.19-4.45)0.014
Tumor location
    Proximal colon vs. RectumProximal colon2.18 (1.24-3.82)0.007
    Distal colon vs. RectumDistal colon1.27 (0.42-3.92)0.674
Tumor stage
    II vs. III3.77 (0.85-16.79)0.081
    III vs. IIII17.17 (1.65-31.21)0.008
    IV vs. IIV27.46 (5.88-128.28)<0.0001
Tumor size
    >5 cm vs. ≤5 cm>5 cm0.41 (0.23-0.74)0.003
Caucasian patients
Codon 72 polymorphism
    Pro/Pro vs. Arg/Arg or Arg/ProPro/Pro1.60 (0.69-3.18)0.277
p53 status
    Mutated vs. wild-typeMutated1.55 (1.04-2.32)0.032
Tumor stage
    II vs. III1.63 (0.74-3.59)0.229
    III vs. IIII4.10 (1.92- 8.77)0.0003
    IV vs. IIV10.71 (4.72-24.29)<0.0001
  • * Adjusted for the p53 codon 72 polymorphism, p53 gene mutations, age, gender, and TNM tumor stage, tumor location within the colorectum, tumor grade, and tumor size.