Table 2.

Summary of patient physiologic and demographic characteristics

(A) Summary values at screening (or first available measurement) of continuous covariates
VariableAge (y)Weight (kg)CrCL (mL/min)*
Minimum1834.032.2
1st quartile4464.074.1
Mean5377.698.2
Median5576.993.5
3rd quartile6488.0118
Maximum87168347
Total N590590587
SD1518.836.7
(B) No. of subjects within a range at screening (or first available measurement)
Demographic(range at screening)
Subgroup
Healthy volunteers
Patients
All
Age, y (18-87)<40633699
40-6010275285
60-750180180
>7502626
Weight, kg (34-168)≥135066
76-<13536271307
41-7537237274
≤40033
CrCL, mL/min (32-347)*>8072318390
50-801168169
30-4902828
<30033
  • * Excludes three subjects with low CrCL values (<1 mL/min; these are thought to be an artifact of the Cockroft-Gault estimation).