Table 3.

Values of final parameter estimates for the base models for sunitinib and SU12662

ParameterEstimate (SE/estimate)Interindividual variability (SE/estimate)Interindividual variability (variance)*
Sunitinib
    CL/F, L/h37.7 (1.8%)37.9% (8.8%)0.14
    Vd/Fcentral, liters1,940 (3.8%)44.7% (13%)0.20
    Ka, 1/h0.195 (6.8%)81.2% (13%)0.66
    Intercompartmental flow (Q/F), L/h6.37 (18%)NANA
    Vd/Fperipheral, liters588 (8.7%)NANA
    Proportional error0.147 (9.6%)NANA
SU12662
    CL/F, L/h20.2 (2.3%)52.2% (8.5%)0.27
    Vd/Fcentral, liters2,710 (3.9%)65.1% (8.7%)0.42
    Ka, 1/h0.287 (6.6%)89.1% (13%)0.79
    Intercompartmental flow (Q/F), L/h27.7 (26%)NANA
    Vd/Fperipheral, liters345 (22%)NANA
    Proportional error0.0913 (7.3%)NANA
  • Abbreviation: NA, not applicable.

  • * Calculated as [%CV/100]2.