Table 3.

Association between dietary PUFA and aggressive prostate cancer

PUFAQuartile of PUFA intake
Ptrend*
1 (reference)234
n-6 PUFAs
    LA 18:2
        Level (g)7.5311.7316.1924.22
        Cases/controls104/12091/119116/120115/119
        Adjusted OR (95% CI)1.00.78 (0.52-1.16)0.88 (0.57-1.35)0.97 (0.56-1.67)0.84
    AA 20:4
        Level (g)0.0750.1260.1770.280
        Cases/controls111/119135/120105/120115/119
        Adjusted OR (95% CI)1.01.00 (0.69-1.44)0.64 (0.43-0.97)0.59 (0.38-0.93)0.37
n-3 PUFAs
    ALA 18:3
        Level (g)0.791.271.752.55
        Cases/controls108/120106/119103/120149/119
        Adjusted OR (95% CI)1.00.83 (0.56-1.23)0.71 (0.46-1.09)0.81 (0.48-1.35)0.11
    EPA 20:5
        Level (g)0.0200.0510.0900.167
        Cases/controls176/119113/120103/12074/119
        Adjusted OR (95% CI)1.00.60 (0.42-0.86)0.50 (0.35-0.71)0.35 (0.24-0.52)<0.0001
    DPA 22:5
        Level (g)0.0080.0200.0340.061
        Cases/controls164/120131/11989/12082/119
        Adjusted OR (95% CI)1.00.71 (0.50-1.01)0.45 (0.31-0.66)0.40 (0.27-0.59)<0.0001
    DHA 22:6
        Level (g)0.0370.0970.1800.368
        Cases/controls175/120112/11992/12077/119
        Adjusted OR (95% CI)1.00.60 (0.42-0.86)0.45 (0.31-0.65)0.36 (0.25-0.53)<0.0001
    LC n-3 PUFAs§
        Level (g)0.0670.1670.2970.588
        Cases/controls173/120119/11995/11979/120
        Adjusted OR (95% CI)1.00.61 (0.43-0.87)0.47 (0.32-0.68)0.37 (0.25-0.54)<0.0001
Total n-3 to total n-6 ratio
        Level0.0960.1180.1360.165
        Cases/controls160/119146/12092/11968/120
        Adjusted OR (95% CI)1.00.94 (0.67-1.33)0.60 (0.42-0.86)0.41 (0.28-0.60)0.0002
LC n-3 to total n-6 ratio
        Level0.0040.0110.0220.047
        Cases/controls173/120140/11988/12065/119
        Adjusted OR (95% CI)1.00.83 (0.59-1.16)0.54 (0.38-0.78)0.41 (0.28-0.60)0.0023
  • * Calculated with actual values as a continuous variable.

  • Midpoint of quartile.

  • Adjusted for calories, age, ethnicity, and institution (n = 944). Adjustment for total fat intake, body mass index, smoking, PSA screening, and family history of prostate cancer did not materially affect the results.

  • § EPA + DPA + DHA.