Table 3.

Incidence of perineural invasion and tumor spread following s.c. injection and orthotopic transplantation of Capan-1: the impact of SNCG gene silencing by 2 different sequences

shRNAsPerineural invasion model
Orthotopic transplantation model
Perineural invasionTumor size, mmAscitesPeritoneal disseminationDistant metastasis
LiverLymph nodesLungs
sh-Control9/11 (82%)19 ± 57/7 (100%)4/7 (57%)4/7 (57%)6/7 (86%)0/7 (0%)
sh-A3/12 (25%)*14 ± 44/9 (44%)1/9 (11%)0/9 (0%)2/9 (22%)0/9 (0%)
sh-B4/12 (33%)17 ± 47/7 (100%)4/7 (57%)2/7 (29%)5/7 (71%)0/7 (0%)
  • * P < 0.01 versus sh-Control.

  • P < 0.05 versus sh-Control.