Table 1.

PK parameters of BI 6727 in rodents

PK parametersBI 6727
RatsMice
i.v.
    Dose (mg/kg)1035
    Cmax (μmol/L)11.97.1
    AUC0-inf (μmol h/L)30100
    CL [min/(min kg)]8.910
    Vss (L/kg)227.6
    t1/2 (h)5446
p.o.
    Dose (mg/kg)3050
    Cmax (μmol/L)2.25.7
    tmax (h)6.71.7
    AUC0-24 (μmol h/L)3458
    F (%)5541