Table 2.

Efficacy of BI 6727 in multiple xenograft models

Cell lineDaily dose (mg/kg)ScheduleRouteWeekly dose (mg/kg/wk)T/C (%)Weekly AUC0-24 (╬╝mol/L)
HCT 11625Twice a weeki.v.500.375
20Twice a weeki.v.40166
15Twice a weeki.v.30137
HCT 11620Once a weeki.v.20940
30Once a weeki.v.30352
HCT 11650Once a weekp.o.50244
25Twice a weekp.o.50243
7Dailyp.o.49344
NCI-H46070Once a weekp.o.702058
10Dailyp.o.70661
CXB115Twice a weeki.v.3012nd
  • Abbreviations: T/C, treated versus control; nd, not determined.