Hematologic toxicities (grade 2 or more)
| Dose level 1 (4 patients) 1st cycle (all cycles) | Dose level 2 (3 patients) 1st cycle (all cycles) | Dose level 3 (10 patients) 1st cycle (all cycles) | Dose level 4 (4 patients) 1st cycle (all cycles) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| G2 | G3 | G4 | G2 | G3 | G4 | G2 | G3 | G4 | G2 | G3 | G4 | |||||||||
| Neutropenia | 0 (1) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (0) | 2 (6) | 1 (2) | 0 (0) | 0 (1) | 0 (2) | 0 (1) | ||||||||
| Anemia | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | ||||||||
| Thrombocytopenia | 0 (0) | 0 (0) | 0 (0) | 0 (1) | 0 (0) | 0 (0) | 2 (1) | 0 (3) | 0 (0) | 0 (1) | 0 (0) | 0 (2) | ||||||||
NOTE: All cycles toxicities are listed in between parenthesis.
Abbreviation: G, grade.