Table 3.

Hematologic toxicities (grade 2 or more)

Dose level 1 (4 patients) 1st cycle (all cycles)
Dose level 2 (3 patients) 1st cycle (all cycles)
Dose level 3 (10 patients) 1st cycle (all cycles)
Dose level 4 (4 patients) 1st cycle (all cycles)
G2G3G4G2G3G4G2G3G4G2G3G4
Neutropenia0 (1)0 (0)0 (0)0 (1)0 (0)0 (0)2 (6)1 (2)0 (0)0 (1)0 (2)0 (1)
Anemia0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)0 (0)
Thrombocytopenia0 (0)0 (0)0 (0)0 (1)0 (0)0 (0)2 (1)0 (3)0 (0)0 (1)0 (0)0 (2)
  • NOTE: All cycles toxicities are listed in between parenthesis.

    Abbreviation: G, grade.