Table 5.

Mean ± SD pharmacokinetic parameters for plasma FU

FU maintenance dose (mg/m2)Vorinostat dose (mg)Css (ηg/mL)Cmax (ηg/mL)AUC (ηg h/mL)
2,4001000.287 ± 0.0445.03 ± 4.3915.3 ± 5.7
2,4002000.274 ± 0.04513.1 ± 7.9624 ± 9.11
2,4003000.396 ± 0.15924.5 ± 14.568.7 ± 88.1
2,4004000.432 ± 0.07726.8 ± 11.446.7 ± 10.6
  • NOTE: ANOVA analysis was done, and only Cmax was statistically significant among the vorinostat treatment groups.

    Abbreviations: Css, steady-state concentration; AUC, area under the curve.