Table 6.

Pharmacokinetic parameters for vorinostat on days 1 and 5

Dose (mg)Day 1
Day 5
Cmax (μmol/L)Tmax (h)AUC (μmol/L h)t1/2 (h)CLapp (l/h)Cmax (μmol/L)Tmax (h)AUC (μmol/L h)t1/2 (h)CLapp (l/h)
100Mean1.2412.42.51.51890.7023.41.91.2202
SD1.0611.91.20.91020.3423.40.40.360
200Mean0.8161.51.91.24000.8942.73.31.6231
SD0.2450.90.30.3540.5401.20.60.739
300Mean1.4581.64.42.32850.9502.46.82.3225
SD0.7121.11.52.0830.5901.14.31.1118
400Mean1.5111.94.53.73451.4752.87.42.2211
SD0.5331.50.63.5480.3631.51.41.440
  • Abbreviation: CLapp, apparent clearance.