Table 2.

Associations between prostate cancer mortality and 8q24/17q variants, comparing prostate cancer deaths with long-term survivors

SNPPHS, OR (95% CI)*Gelb Center, OR (95% CI)*FHCRC, OR (95% CI)*Combined, OR (95% CI)
rs13254738P = 0.54P = 0.38P = 0.75P = 0.35
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC1.23 (0.86-1.77)1.21 (0.80-1.85)0.88 (0.44-1.78)1.17 (0.90-1.51)
    CC1.12 (0.65-1.91)1.24 (0.60-2.56)0.90 (0.29-2.76)1.12 (0.75-1.68)
rs6983561P = 0.81P = 0.54P = 0.66P = 0.49
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC/CC0.93 (0.52-1.68)0.80 (0.38-1.65)0.79 (0.27-2.36)0.86 (0.56-1.32)
rs6983267P = 0.97P = 0.57P = 0.31P = 1.00
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT0.82 (0.52-1.27)1.51 (0.89-2.54)0.85 (0.36-2.00)1.04 (0.68-1.58)
    GG0.96 (0.59-1.54)1.24 (0.70-2.21)0.59 (0.21-1.66)1.00 (0.70-1.41)
rs7000448P = 0.06P = 0.39P = 0.57P = 0.10
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CT0.80 (0.56-1.15)1.17 (0.75-1.83)1.21 (0.58-2.52)0.97 (0.74-1.27)
    TT0.60 (0.34-1.06)0.70 (0.40-1.24)1.30 (0.44-3.83)0.70 (0.48-1.03)
rs1447295P = 0.88P = 0.64P = 0.84P = 0.65
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CA/AA1.03 (0.69-1.55)1.12 (0.70-1.80)1.08 (0.51-2.30)1.07 (0.80-1.42)
rs7008482P = 0.47P = 0.50P = 0.87
    TT1.00 (reference)1.00 (reference)1.00 (reference)
    GT1.04 (0.72-1.49)1.05 (0.69-1.61)1.04 (0.79-1.38)
    GG1.26 (0.73-2.17)0.66 (0.32-1.35)0.95 (0.51-1.79)
rs4430796P = 0.70P = 0.57P = 0.91P = 0.43
    GG1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AG1.13 (0.72-1.77)0.96 (0.57-1.64)0.44 (0.18-1.07)0.89 (0.57-1.39)
    AA0.93 (0.56-1.56)0.86 (0.48-1.51)0.80 (0.34-1.86)0.88 (0.62-1.25)
rs1859962P = 0.82P = 0.08P = 0.90P = 0.47
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT1.02 (0.67-1.56)1.68 (1.01-2.81)1.03 (0.44-2.42)1.22 (0.87-1.71)
    GG0.95 (0.60-1.52)1.73 (0.97-3.06)0.95 (0.36-2.47)1.18 (0.78-1.79)
  • * All results from unconditional logistic regression, adjusted for age at diagnosis.

  • All P values for 1-degree-of-freedom test.

  • P < 0.05.