Table 3.

Associations between Gleason score and 8q24/17q variants, comparing men with Gleason score 8 to 10 with Gleason score 2 to 6

SNPPHS, OR (95% CI)*Gelb Center, OR (95% CI)*FHCRC, OR (95% CI)*Combined, OR (95% CI)
rs13254738
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC1.10 (0.77-1.57)0.90 (0.74-1.09)0.85 (0.56-1.29)0.93 (0.79-1.09)
    CC1.09 (0.64-1.87)0.90 (0.66-1.23)1.35 (0.75-2.40)1.01 (0.79-1.29)
rs6983561
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC/CC1.10 (0.62-1.95)1.01 (0.72-1.41)0.98 (0.53-1.83)1.02 (0.79-1.33)
rs6983267
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT0.84 (0.54-1.30)0.80 (0.63-1.00)0.86 (0.52-1.42)0.82 (0.67-0.99)
    GG1.15 (0.72-1.82)0.68 (0.53-0.87)0.93 (0.54-1.61)0.85 (0.61-1.20)
rs7000448
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CT0.97 (0.68-1.39)0.88 (0.72-1.08)1.00 (0.66-1.52)0.91 (0.78-1.07)
    TT0.84 (0.49-1.41)0.89 (0.68-1.17)0.82 (0.42-1.58)0.87 (0.70-1.09)
rs1447295
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CA/AA0.88 (0.59-1.31)1.10 (0.89-1.36)0.88 (0.56-1-39)1.02 (0.86-1.22)
rs7008482
    TT1.00 (reference)1.00 (reference)1.00 (reference)
    GT0.82 (0.58-1.17)0.87 (0.72-1.06)0.86 (0.73-1.02)
    GG1.08 (0.63-1.85)0.76 (0.56-1.03)0.84 (0.62-1.15)
rs4430796
    GG1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AG1.08 (0.69-1.69)0.97 (0.77-1.23)1.03 (0.62-1.71)1.00 (0.82-1.21)
    AA1.04 (0.63-1.71)0.96 (0.74-1.25)0.92 (0.53-1.59)0.97 (0.78-1.20)
rs1859962
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT1.28 (0.84-1.93)1.05 (0.84-1.32)0.88 (0.55-1.42)1.06 (0.88-1.28)
    GG0.98 (0.61-1.59)1.00 (0.77-1.30)0.82 (0.48-1.42)0.97 (0.78-1.20)
  • * All results from unconditional logistic regression, adjusted for age at diagnosis.

  • P < 0.05.