Table 4.

Associations between stage and 8q24/17q variants, comparing men with pathologic stage T3/T4 with pathologic stage T2

SNPPHS, OR (95% CI)*Gelb Center, OR (95% CI)*FHCRC, OR (95% CI)*Combined, OR (95% CI)
rs13254738P = 0.61P = 0.78P = 0.43P = 0.68
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC1.23 (0.77-1.97)1.15 (0.91-1.47)1.11 (0.79-1.57)1.15 (0.96-1.38)
    CC0.63 (0.29-1.38)0.94 (0.64-1.37)1.19 (0.72-1.97)0.96 (0.73-1.28)
rs6983561P = 0.44P = 0.24P = 0.23P = 0.20
    AA1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AC/CC0.73 (0.33-1.63)1.28 (0.85-1.93)1.36 (0.83-2.25)1.21 (0.90-1.63)
rs6983267P = 0.94P = 0.007P = 0.89P = 0.27
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT0.56 (0.31-0.99)*0.73 (0.55-0.97)0.92 (0.59-1.43)0.74 (0.60-0.93)
    GG0.91 (0.50-1.68)0.65 (0.47-0.88)1.01 (0.62-1.63)0.79 (0.59-1.05)
rs7000448P = 0.38P = 0.14P = 0.70P = 0.09
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CT0.64 (0.39-1.03)0.87 (0.68-1.12)1.03 (0.73-1.45)0.87 (0.70-1.08)
    TT0.91 (0.48-1.73)0.78 (0.55-1.11)0.86 (0.51-1.45)0.82 (0.63-1.07)
rs1447295P = 0.49P = 0.75P = 0.37P = 0.67
    CC1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    CA/AA1.21 (0.71-2.05)0.96 (0.73-1.25)0.84 (0.57-1.23)0.96 (0.78-1.17)
rs7008482P = 0.83P = 0.02P = 0.03
    TT1.00 (reference)1.00 (reference)1.00 (reference)
    GT1.12 (0.70-1.78)0.89 (0.70-1.13)0.93 (0.76-1.15)
    GG0.76 (0.33-1.75)0.57 (0.37-0.87)0.61 (0.41-0.89)
rs4430796P = 0.63P = 0.77P = 0.95P = 0.97
    GG1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    AG1.06 (0.56-1.97)0.84 (0.62-1.13)0.82 (0.54-1.25)0.86 (0.69-1.07)
    AA0.89 (0.45-1.74)1.01 (0.73-1.39)0.95 (0.60-1.49)0.98 (0.76-1.25)
rs1859962P = 0.21P = 0.07P = 0.36P = 0.54
    TT1.00 (reference)1.00 (reference)1.00 (reference)1.00 (reference)
    GT0.99 (0.57-1.72)1.36 (1.01-1.83)1.32 (0.87-1.99)1.28 (1.03-1.60)
    GG0.68 (0.36-1.28)1.39 (1.00-1.92)1.26 (0.80-2.00)1.14 (0.79-1.65)
  • * All results from unconditional logistic regression, adjusted for age at diagnosis.

  • All P values for 1-degree-of-freedom test.

  • P < 0.05.