Table 5.

Mean values of age at diagnosis by 8q24/17q genotypes and cumulative number of risk alleles

SNPPHS, mean (SE)*Gelb Center, mean (SE)*FHCRC, mean (SE)*
rs13254738P = 0.94P = 0.0004P = 0.26
    AA70.6 (0.3)61.4 (0.2)59.7 (0.3)
    AC70.4 (0.3)62.4 (0.2)60.3 (0.3)
    CC70.5 (0.6)62.8 (0.4)59.6 (0.6)
rs6983561P = 0.43P = 0.25P = 0.80
    AA70.5 (0.2)62.0 (0.1)60.0 (0.2)
    AC/CC70.0 (0.7)61.4 (0.5)59.8 (0.6)
rs6983267P = 0.20P = 0.003P = 0.59
    TT71.0 (0.5)62.7 (0.3)60.3 (0.5)
    GT70.6 (0.3)62.1 (0.2)59.9 (0.3)
    GG70.0 (0.4)61.4 (0.2)59.7 (0.4)
rs7000448P = 0.88P = 0.10P = 0.81
    CC70.6 (0.3)62.1 (0.2)60.1 (0.3)
    CT70.4 (0.3)61.8 (0.2)59.9 (0.3)
    TT70.7 (0.5)62.6 (0.3)59.7 (0.6)
rs1447295P = 0.33P = 0.06P = 0.21
    CC70.6 (0.2)62.2 (0.2)59.8 (0.2)
    CA/AA70.1 (0.4)61.5 (0.3)60.4 (0.4)
rs7008482P = 0.70P = 0.22
    TT70.7 (0.3061.8 (0.2)
    GT70.4 (0.3)62.1 (0.2)
    GG70.3 (0.6)62.4 (0.4)
rs4430796P = 0.08P = 0.02P = 0.30
    GG71.0 (0.5)62.5 (0.3)60.3 (0.5)
    AG70.7 (0.3)62.1 (0.2)60.1 (0.3)
    AA69.8 (0.4)61.5 (0.3)59.5 (0.3)
rs1859962P = 0.25P = 0.03P = 0.67
    TT70.6 (0.4)62.4 (0.3)60.2 (0.4)
    GT70.8 (0.3)62.1 (0.2)60.0 (0.3)
    GG70.0 (0.4)61.5 (0.3)59.7 (0.4)
No. risk allelesP = 0.008P = 0.0004P = 0.40
    0-272.1 (0.6)63.7 (0.4)60.2 (0.6)
    371.2 (0.5)62.1 (0.3)59.8 (0.5)
    470.3 (0.4)61.7 (0.3)60.7 (0.4)
    570.0 (0.4)61.6 (0.3)59.5 (0.4)
    6-969.7 (0.5)61.8 (0.3)59.7 (0.4)
  • * All results from ANOVA.