χ2 and P values for xenograft studies
| PLD vs IL-PLD dose-response study (Fig. 3) | χ2 | P |
|---|---|---|
| Ctrl vs 8 mg/kg PLD single dose | 0.1454 | 0.7029 |
| Ctrl vs 12 mg/kg PLD single dose | 2.496 | 0.1141 |
| Ctrl vs 16 mg/kg PLD single dose | 7.504 | 0.0062 |
| Ctrl vs 8 mg/kg 3 doses | 3.646 | 0.0562 |
| Ctrl vs 8 mg/kg IL-PLD single dose | 4.795 | 0.0285 |
| Ctrl vs 12 mg/kg IL-PLD single dose | 4.922 | 0.0265 |
| Ctrl vs 16 mg/kg IL-PLD single dose | 7.504 | 0.0062 |
| Ctrl vs 8 mg/kg IL-PLD 3 doses | 7.504 | 0.0062 |
| PLD vs 8 mg/kg IL-PLD single dose | 6.8 | 0.0091 |
| PLD vs 12 mg/kg IL-PLD single dose | 0.7242 | 0.3948 |
| PLD vs 16 mg/kg IL-PLD single dose | 0.02425 | 0.8762 |
| PLD vs 8 mg/kg IL-PLD 3 doses | 7.344 | 0.0067 |
| 8 mg/kg PLD single dose vs 8 mg/kg PLD 3 doses | 4.795 | 0.0285 |
| 8 mg/kg IL-PLD single dose vs 8 mg/kg IL-PLD 3 doses | 4.268 | 0.0388 |
| PLD vs IL-PLD vs IL-null study (Fig. 4) | χ2 | P |
| Ctrl vs PLD | 20.5 | <0.0001 |
| Ctrl vs IL-PLD | 26.5 | <0.0001 |
| Ctrl vs PLD + free HB22.7 | 10.79 | 0.001 |
| Ctrl vs IL-null | 11.48 | 0.0007 |
| IL-PLD vs PLD | 12.94 | 0.0003 |
| IL-PLD vs PLD + free HB22.7 | 14.87 | 0.0001 |
| IL-PLD vs IL-null | 9.824 | 0.0017 |
| PLD vs PLD + free HB22.7 | 0.3052 | 0.5806 |
| PLD vs IL-null | 0.08097 | 0.776 |
| IL-null vs PLD + free HB22.7 | 0.1559 | 0.693 |
NOTE: Data were analyzed using the modified Kaplan- Meier curves and the Log-rank test as described in Materials and Methods. Comparisons with significant P values (<0.05) are shown in bold.
Abbreviation: Ctrl, control.