Table 1.

Association of clinicopathologic variables with TMPRSS2:ERG fusion and SPINK1 expression

VariableTMPRSS2:ERG fusion according to FISH (%)PSPINK1 expression according to immunohistochemistry (%)*P
No fusionFusionNegativePositive
All samples117 (66)61 (34)165 (89)21 (11)
Gleason score, n (%)
    <734 (76)11 (24)41 (85)7 (15)
    734 (65)18 (35)50 (93)4 (7)
    >745 (60)30 (40)0.220668 (87)10 (13)0.4849
T stage, n (%)
    T1-274 (70)31 (30)99 (91)10 (9)
    T3-443 (60)30 (40)0.109666 (86)11 (14)0.2780
M stage, n (%)
    M042 (66)22 (34)57 (88)8 (12)
    M113 (56)10 (44)0.45938 (67)4 (33)0.4391
PSA ng/mL (mean ± SD)§206 ± 109278 ± 2160.3641105 ± 42963 ± 1040.6528
Ki-67% (mean ± SD)6.6 ± 5.39.8 ± 6.90.00107.6 ± 6.17.8 ± 5.10.6618
Age (mean ± SD)§74.3 ± 7.271.9 ± 5.90.024373.8 ± 6.871.6 ± 8.40.1728
Tumor area % (mean ± SD)24.3 ± 24.237.1 ± 29.90.005928.6 ± 26.633.7 ± 31.10.4252
  • *SPINK1 expression classified as positive when the intensity was 3 and the surface area stained was >10%.

  • χ2 test.

  • Fisher's exact test.

  • §Variance analysis.

  • Mann-Whitney test.

  • Variance analysis with Welch correction.