Table 1.

Association of clinicopathologic variables with TMPRSS2:ERG fusion and SPINK1 expression

Variable	TMPRSS2:ERG fusion according to FISH (%)		P	SPINK1 expression according to immunohistochemistry (%)^*		P
Variable	No fusion	Fusion	P	Negative	Positive	P
All samples	117 (66)	61 (34)		165 (89)	21 (11)
Gleason score, n (%)^†
<7	34 (76)	11 (24)		41 (85)	7 (15)
7	34 (65)	18 (35)		50 (93)	4 (7)
>7	45 (60)	30 (40)	0.2206	68 (87)	10 (13)	0.4849
T stage, n (%)^†
T_1-2	74 (70)	31 (30)		99 (91)	10 (9)
T_3-4	43 (60)	30 (40)	0.1096	66 (86)	11 (14)	0.2780
M stage, n (%)^‡
M₀	42 (66)	22 (34)		57 (88)	8 (12)
M₁	13 (56)	10 (44)	0.4593	8 (67)	4 (33)	0.4391
PSA ng/mL (mean ± SD)^§	206 ± 1092	78 ± 216	0.3641	105 ± 429	63 ± 104	0.6528
Ki-67% (mean ± SD)^∥	6.6 ± 5.3	9.8 ± 6.9	0.0010	7.6 ± 6.1	7.8 ± 5.1	0.6618
Age (mean ± SD)^§	74.3 ± 7.2	71.9 ± 5.9	0.0243	73.8 ± 6.8	71.6 ± 8.4	0.1728
Tumor area % (mean ± SD)^¶	24.3 ± 24.2	37.1 ± 29.9	0.0059	28.6 ± 26.6	33.7 ± 31.1	0.4252

↵*SPINK1 expression classified as positive when the intensity was 3 and the surface area stained was >10%.
↵^†χ² test.
↵^‡Fisher's exact test.
↵^§Variance analysis.
↵^∥Mann-Whitney test.
↵^¶Variance analysis with Welch correction.