Frequency of patients with bleeding events
| Below MTD (n = 12) | At MTD (n = 12) | Above MTD (n = 2) | Total (n = 26) | |
|---|---|---|---|---|
| Patients with any bleeding events* [n (%)] | 7 (58.3) | 3 (25.0) | 1 (50.0) | 11 (42.3) |
| CTCAE grade of most intense bleeding event [n (%)] | ||||
| CTCAE grade 1 | 6 (50.0) | 2 (16.7) | 1 (50.0) | 9 (34.6) |
| CTCAE grade 2 | 1 (8.3) | 1 (8.3) | 0 (0.0) | 2 (7.7) |
| Patients with drug-related bleeding event [n (%)] | 4 (33.3) | 0 (0.0) | 0 (0.0) | 4 (15.4) |
| Patients with any bleeding event determined to be DLT [n (%)] | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
↵*Bleeding events include the MedDRA PT of “epistaxis,” “hematuria,” “hemoptysis,” and “rectal hemorrhage.”